N-Acetyl Cysteine (NAC)


*Introduction 1,2,3,4

N-acetyl cysteine is derived from the amino acid cysteine. N-acetyl cysteine may help maintain optimal cysteine levels in the body. This is vital since cysteine is considered the rate limiting substrate for the synthesis of glutathione. Another way to say this is that without sufficient cysteine your body cannot make glutathione. Insufficient glutathione is disastrous for your body since glutathione is one of the most formidable natural anti-oxidants and detoxifiers the body produces. Glutathione is on the same level as Vitamin C and Vitamin E in terms of importance. Some special characteristics of glutathione are its ability especially to help protect muscle and joint cells against fat oxidation and foreign toxins.

  *Potential Benefit of N-Acetyl Cysteine for Joint and Muscle Health


 *NAC is an anti-oxidant 5,6,7,8,9

Rampant oxidation magnifies and accelerates chronic joint and muscle injury. NAC acts both as an indirect and direct ant-oxidant. NAC acts indirectly by boosting the synthesis of glutathione. As previously mentioned, glutathione is a remarkable endogenous antioxidant that protects muscle and joint tissue from various types a toxins and oxidative stress. Moreover, NAC exhibits direct antioxidant properties with research suggesting that NAC directly neutralizes free radicals.

 *NAC may reduce fatigue 10,11,12,13,14

Fatigue and lack of endurance are frequent complaints of individuals with chronic joint and muscle disease. Investigation implies NAC may directly and indirectly lessen the onset of fatigue and prolong one’s ability to perform intense exercises. While the exact mechanism is unknown, NAC anti-oxidation attributes likely contribute. This underscores the prominent role oxidative stress plays in the onset of fatigue.

 *NAC may prevent muscle damage and soreness 15,16

Muscle loss and lingering local muscle inflammation are common findings in chronic muscular and joint injury. Research suggests NAC may help reduce the oxidative damage induced by inflammation.

 *Safety First 17,18

NAC is generally well tolerated. Some research suggested co-supplementation of high dose Vitamin C and NAC may magnify oxidative stress. However, these findings have yet to be reproduced and may represent an aberration. As with any consideration of any form of supplementation consult your healthcare provide prior to use if you are pregnant, nursing, taking any medications or have any medical conditions. Discontinue use and consult your doctor is any adverse reactions occur.

*These statements have not been evaluated by the Food and Drug Administration. These statements are not intended to diagnose, treat, cure or prevent any disease.



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