Organo Sulfur Compounds

Allium and cruciferous vegetables are an excellent addition to any strategy to promote joint, muscle, bone, and tendon health. Allium and cruciferous vegetables are a rich source of organo sulfur compounds. Organo sulfur compounds are a subclass of organic substances that contain sulfur and  have been utilized for thousands of years to remedy human disease and more recently as life-saving antibiotics, such as penicillin and cephalosporins .

As sulfur is essential for life, nature is teeming with organo sulfur compounds.These compounds are found in a wide variety of locations, including interstellar space, deep within the ocean, and inside hot volcanoes. They can be found in the bodies of all living things in the form of some amino acids,  coenzymes, hormones, and vitamins.


Musculoskeletal health benefits of organo sulfur compounds

Chronic disease of bone, muscle, tendon, and joint, at least in part, share a common destructive pathway governed by excessive inflammation and oxidative stress. While the exact manner in which organosulfur substances promote musculoskeletal well being is unknown the likely mechanism is its reduction of chronic oxidative stress and inflammation.


Organo sulfur compounds possess impressive antioxidant attributes. Scientific data indicates that organosulfur compounds display a variety of antioxidant properties:

  • Direct quenching of high energy, destructive free radicals
  • Boost the potency of glutathione and glutathione disulfide reductase. Glutathione is the body's bulwark against oxygen free radicals, oxidized fat, and heavy metal toxins.
  • Enhance superoxide dismutase activity, the body’s best defense against super dangerous oxygen molecules called superoxide anions.


Organo sulfur derivatives provide multi pronged defense against chronic inflammation. Reserarch has demonstrated that organo sulfur compounds:

  • Thwart Nuclear Factor-kB(NF-kB) pathway activation. NF-kB directs the activation of sequences of DNA that magnify inflammation
  • Suppress the activity of  Tumor Necrosis Factor Alpha and IL-1B, two master signaling molecules that orchestrate chronic inflammation 
  • Decrease the synthesis of COX-2 enzyme. COX-2 enzymes produce substances called prostaglandins that cause pain and swelling
  • Reduce production of matrix metalloproteinases, substances that breakdown healthy tissue

Selected Evidence

1. Organo sulfur Compounds Support Joint Health

Population twin studies from England identified a potential protective effect of allium vegetables against osteoarthritis.  When examining pairs of twins with near identical genetics, the twin that consumed allium vegetables on a regular basis had a significantly less likelihood of developing osteoarthritis. (Skinner et al. BMC Musculoskelet Disord. 2010 Dec 8;11:280)

2. Organo sulfur Compounds Support Bone Health

Researchers in China exposed mouse bone resorbing cells called osteoclasts to a garlic extract high in allium. The investigators concluded that the extract reduced the production of bone resorbing cells by reducing the cells exposure to free radicals and oxidative stress. Excessive bone resorption is the cardinal cause of osteoporosis. (Chen et al. Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox1.Int J Mol Sci. 2016 Sep 20;17(9). pii: E1516.)

3. Organo sulfur Compound Supports Muscle Health

Chinese investigators administered sulforaphane to mice and assessed its effect on muscle inflammation. The researchers found that sulforphane reduced muscle inflammation by reducing the influx of immune cells into muscle tissue and decreasing the production of inflammation promoting cytokines. (Cheng-Cao Sun et al. Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway. J Biol Chem. 2015 Jul 17; 290(29): 17784–17795.)

Other Health benefits of organo sulfur compounds

According to research, eating cruciferous vegetables and garlic is linked with several health benefits:

  • Reduces risk of colorectal and stomach cancers 
  • Gives strength and resiliency to hair
  • Supports healthy blood sugar
  • Promotoes heart and blood vessel health

How to properly prepare these vegetables in order to preserve their compounds


For broccoli, the best way is to steam. Study found that steaming gives the sulforaphane 3 times more bioavailable than heavy cooking.

Onions and garlic

The best way to eat these allyl sulfur compounds is to eat them raw. So chopping up some onion and garlic and mixing them into your salad will give you most of the benefits of these compounds.


Research has shown that you can get more bioavailable organosulfur compounds from your cabbage if you lightly steam them. Cooking in high heat in the microwave destroys many of these beneficial compounds. Chop it up to your desired consistency and then let sit for a few minutes. Steam for four to five minutes. If you want to use the microwave, use the low or medium setting.


Cut into small florets and then let sit for ten minutes; it’ll allow the myrosinase enzyme to do its job and make glucosinates more available. Now, steam or bake them. One delicious recipe: Bake a few small florets of cauliflower and mix them with curry powder, turmeric, cayenne, salt and olive oil.

Brussels sprouts

Best way to prepare Brussels sprouts is to quarter and stem them for 5 minutes. Remove them from the steamer and toss with olive oil or butter.

Best natural sources of foods high in sulfur

Cruciferous Vegetables

Cruciferous vegetables including broccoli, cabbage, cauliflower, Brussels sprouts, kale, bok choy, turnips, and kohlrabi, are packed with glucosinolates, which give them a pungent aroma and slightly bitter taste.

Allium Vegetables

Onions, garlic, leeks and chives, contain organosulfur compounds.



Organo sulfur compounds from natural foods is generally well tolerated. 

High intake may cause mild gastrointestinal symptoms, breath and body odor. High dose supplementation may enhance anti-coagulation effects of blood thinners and decrease the bioavailability of HIV protease inhibitors. 

Any consideration a supplementation should be discussed with a qualified health professional familiar with your unique medical history.


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